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To set up Microsoft Outlook Express:
1 Open Microsoft Outlook Express.
2 Go to Tools > Accounts.
3 Click the Mail tab to open a list of your mail accounts.
4 Click the Add button and select the Mail item.
5 Enter your name as you want it to appear in any messages you send, and click 
Next .
6 Type your e-mail address that you created through Plesk (for example, 
your.name@your-domain.com), and click Next .
7 Select the protocol of your incoming mail server.
8 Specify the mail domain name as the incoming and outgoing mail server (for 
example: mail.your-domain.com), and click Next .
9 Type your e-mail address in the Account name box (for example: 
your.name@your-domain.com).
10 Type your password. This should be the password that you specified during 
creation of the mailbox through Plesk.
11 Leave the Remember password box checked, if you do not wish to be 
prompted to enter password each time your e-mail program connects to the mail 
server to check for new mail, and click Next .
12 To complete initial setup of your e-mail account, click Finish.

Important: This SMTP server requires Authentication.
Once the account is set up, you must:
>From the "Tools" menu, choose "Accounts"
>Select the proper email account from the list, then choose, the "Properties" 
button.
>Select the "Servers" tab.
>Be sure the box, "My server requires authentication" is checked.
>Then click the "Settings" button.
>You can actually choose either of the options, but the most reliable is to select 
the "Logon using" Option and put your email address and password in the boxes.
Do not check the "Logon using secure authentication" check box.

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To set up Mozilla Thunderbird:
1 Open Mozilla Thunderbird.
2 Go to Tools > Account Settings
3 Click Add Account. The Account Wizard will open.
4 Leave the Email account option selected, and click Next.
5 Enter your name as you want it to appear in any messages you send.
6 Type your e-mail address that you created through Plesk.
For example, your.name@your-domain.com. Click Next.
7 Select the protocol of your incoming mail server.
8 Specify the mail domain name as the incoming and outgoing mail server (for 
example: mail.your-domain.com), and click Next.
9 In the Incoming User Name box, specify your full e-mail address (for example, 
your.name@your-domain.com), and click Next.
10 Enter the name by which you would like to refer to this account (for example, 
Work Account) and click Next.
11 Verify that the information you entered is correct, and click Finish.
12 Click OK to close the Account Settings wizard.